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2008 Kyoto Prize Laureates
Basic Sciences
Prize Field: Life Sciences (Molecular Biology, Cell Biology, Neurobiology)
Anthony James Pawson
Molecular Biologist
Affiliation: Samuel Lunenfeld Research Institute of Mount Sinai Hospital; Professor, University of Toronto
Title: Distinguished Investigator
Date of Birth: October 18, 1952
Nationality: Canada, U.K.
Background: Dr. Pawson proposed and proved the concept that a unique adapter structure exists in signaling proteins, and that the binding of adapters to specific phosphotyrosine-containing domains induces cascades of intracellular signaling that controls cellular growth and differentiation. This concept has established one of the basic paradigms of signal transduction and significantly contributed to the development of the life sciences.
| Brief Biography: |
1952 |
Born in Maidstone, U.K. |
| 1976 |
Ph.D. (Molecular Biology), London University |
| 1976-1980 |
Postdoctoral Research Fellow, University of California, Berkeley |
| 1981-1985 |
Assistant Professor, Department of Microbiology, The University of British Columbia |
| 1985-2006 |
Senior Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital |
| 1985-1988 |
Associate Professor, Department of Medical Genetics and Microbiology, University of Toronto |
| 1989-present |
Full Professor, Department of Medical Genetics and Microbiology (now Department of Molecular Genetics), University of Toronto |
| 1998-present |
University Professor, University of Toronto |
| 2000-2005 |
Director of Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital |
| 2006-present |
Distinguished Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital |
| Selected Awards and Honors: |
| 1994 |
International Award, Gairdner Foundation |
| 2000 |
Officer of the Order of Canada |
| 2005 |
Wolf Foundation Prize in Medicine, Wolf Foundation |
| 2005 |
The Royal Medal, Royal Society of London |
| 2006 |
Order of the Companions of Honour |
| Member: |
Royal Society of London, Royal Society of Canada, National Academy of Sciences, American Academy of Arts and Sciences |
| Selected Publications: |
| 1984 |
Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesi (Stone, J. C., Atkinson, T., Smith, M. E. and Pawson, T.). Cell 37: 549-558. |
| 1986 |
A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps (Sadowski, I., Stone, J. C. and Pawson, T.). Molecular Cellular Biology 6: 4396-4408. |
1990 |
Binding of SH2 domains of phospholipase CΥ1, GAP and Src to activated growth factor receptors (Anderson, D., Koch, C. A., Grey, L., Ellis, C., Moran, M. F. and Pawson, T.). Science 250: 979-982. |
| 1990 |
Src homology region 2 domains direct protein-protein interactions in signal transduction (Moran, M., Koch, C. A., Anderson, D., Ellis, L., England, L., Martin, G. S. and Pawson, T.). Proceeding National Academy of Sciences, U.S.A. 87: 8622-8626. |
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